If you’ve been in aesthetics long enough, you know trends come and go. But every so often, something comes along that isn’t just hype – it’s a genuine game-changer. Right now, that “something” is polynucleotides.
Here at Harley Street Institute, we’ve been watching the buzz around PNs grow, and we think it’s time every clinician starts taking notice. This isn’t just another injectable; it’s a regenerative treatment that could reshape the way we think about skin health.
Think of them as the building blocks of DNA — long strands of nucleotides that can kick-start your skin’s repair systems. They’re usually purified from sources like salmon or trout (don’t worry, they’re highly refined and safe), and when injected, they get busy telling your cells to work harder, heal better, and produce more of the good stuff — collagen, elastin, and all the things that keep skin looking fresh and resilient.
Where fillers “fill” and toxins “relax,” polynucleotides work on a deeper level. They don’t just make skin look better — they help it be better.
Polynucleotides aren’t about a quick fix. They’re about long-term skin quality, and that’s something patients are starting to demand. Here’s why they’re worth your attention:
They regenerate, not just rejuvenate
Instead of temporarily camouflaging ageing signs, they actively improve tissue health.
They’re versatile
We’re talking fine lines, laxity, uneven tone, acne scarring, and even post-treatment healing.
They play well with others
Combine them with microneedling, PRP, energy devices, or even fillers for boosted results.
They’re safe
Highly purified and biocompatible, with minimal risk of reaction.
The “frozen” look is fading out. Patients want to look refreshed, not done. They’re becoming more informed, asking about collagen stimulation, cell repair, and regenerative treatments.
Polynucleotides fit this perfectly — they work gradually, so patients see their skin steadily improve in texture, elasticity, and glow over weeks and months. No dramatic overnight change, just a fresher, healthier version of themselves.
We’ve started introducing PNs into our advanced training courses for injectors, focusing on:
Techniques that ensure they reach the right tissue layers.
Treatment planning so PNs complement other modalities.
Patient conversations to set realistic expectations about the regenerative process.
It’s about making sure practitioners feel confident delivering these treatments — safely, effectively, and ethically.
Polynucleotides represent a shift in aesthetics: from simply filling gaps to activating biology. They’re not a fad; they’re part of the move towards treatments that support the skin’s own systems.
If you’re a clinician who wants to stay ahead of the curve, now’s the time to get familiar. At Harley Street Institute, we believe the future of aesthetics isn’t just about looking younger — it’s about helping skin work better, for longer.
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Thinking about adding Botox treatments to your practice? 💉
Hear directly from one of our students at Harley Street Institute as they share their experience on our Botox Course for Medics. From the moment they joined, they received extensive hands-on training and real practical experience designed specifically for professionals like dentists and medical practitioners looking to expand into aesthetics.
Whether you’re completely new to Botox or already practising and want to refine your skills, this course gives you the confidence to start offering treatments such as masseter Botox and other aesthetic procedures that can help attract more patients and grow your clinic.
✔ Practical, hands-on learning
✔ Perfect for dentists & medics
✔ Learn procedures you can add to your clinic straight away
Ready to get started?
💬 Comment “Guide” and we’ll send you our free guide on how to enrol.
📩 Or DM us for all the details.
🌐 You can also book now through our website and secure your place in the next training session.
Visit harleystreetinstitute.com, Link in the bio for our masseter Botox course -2 our CPD approved
#Injectionskills by Harley Street Institute #aestheticmedicine
Do you inject the Vermillion border in young clients with a perfectly defined border?
#blameitonmigration #lip #dermalfiller #aesthetictraining
While Botox is great to reduce muscle activity and lines, dermal filler actually fills the cavity of the line; converting static lines to dynamic ones
During our certificate in aesthetic medicine (3 days) injection skills are properly developed using various types of needles and cannula. What you are learning is injection depths.
If feels like a gamble that’s your sign to speak to someone from our team to get your headspace certain if this is for you. Comment “CAM” and my team will reach out to you #aestheticcareers #cliniceducator #aesthetic
Trying to figure it out on your own is how you get overwhelmed! This is why my team put 15 min aside to help bring you clarity - comment “CAM” below and my team will reach out to you #aesthetics #aestheticeducation #aestheticeducationworldwide
Remember slow and steady is way better than not taking action. Curious on how you can transition into aesthetics comment “CAM” and I’ll personally reach out to you #aestheticclinic #aestheticeducation
Investing into something new will always come with these thoughts, it’s your duty to make sure you’re investing into courses that feel aligned - that’s why our team put aside 15 minutes a day to help you gain clarity on what is necessary for you to move the needle with aesthetics. Comment “CAM” and I’ll personally reach out #aestheticcourses #aestheticsclinic #education
Aesthetic Talk with Dr Ahmed Haq
If you think you know aesthetics… think again.
Read on https://www.harleystreetinstitute.com
#aestheticmedicine #harleystreetinstitute #aesthetictraining
Link in bio
Biofilm is a rare complication of dermal fillers; however, its incidence varies significantly between clinics, with some encountering it very infrequently and others seeing it more often.
This article explores the real-world experience of a single clinic, supported by relevant research. Read the article to deepen your understanding and gain certification toward your continuing professional development (CPD). #aestheticmedicine
It’s common to have fear when investing into aesthetic courses, as it can feel like a ‘risk’. If you want to understand how to enter aesthetics in a calm, structured, low risk way. Comment ‘CAM’ and I’ll walk you through it
It’s not a complete career change, it’s an expansion of the medical world. Which is why we ONLY train medical professionals. Comment ‘CAM’ below and I’ll DM you more
Botulinum Toxin Top-Up: Forehead, Frown & Crow’s Feet
In this male patient, the upper forehead has relaxed well; however, there is compensatory hyperactivity directly over the eyebrows, resulting in visible movement and line formation. I’m addressing this with very superficial micro-drops, using a 32G needle, keeping the dose conservative at ≤1 unit per injection point to soften activity without risking brow heaviness.
Moving to the frown complex, I first assess which components are still active. In this case, the medial corrugators are adequately relaxed, while the lateral corrugator remains dominant, driving the residual frown expression. Although the contraction appears central, the top-up is strategically placed laterally, targeting the true source of movement rather than the visible crease.
Finally, for the crow’s feet, if lower lateral eye lines become accentuated following initial treatment, I often recommend a small, controlled top-up of 1–2 units into the lower crow’s feet, placed superficially and laterally. This refines residual lines while maintaining smile dynamics and avoiding unwanted diffusion into the zygomaticus.#botoxinjections #botoxtraining
The Truth About Trendy Lips
We need to stop treating lips like a construction project. This dynamic, delicate structure is being ruined by over-manipulation and trendy, trauma-inducing techniques.
The outcome of chasing these “fancy” names? Long-term fibrosis and the look everyone judges: overdone and unnatural.
Don’t be that person. Don’t let your practitioner get sucked into the marketing games. Let’s protect the integrity of a great procedure. Our motto? K.I.S.S. (Keep It Simple, Stupid).#kisslips
Forehead Indentations Explained
Not all forehead dips are created equal — some come from the soft tissues, and others from the hard bony foundation underneath.
🔹 Soft Tissue Causes
The forehead skin is thick and tightly bound down by fibrous connective tissue. These tethering points can pull the skin inward, leaving little dimples or grooves. With age, soft tissue thinning and volume loss make these dips appear more obvious.
🔹 Bony Irregularities
Sometimes, the issue lies deeper. The forehead bone itself can have slight irregularities or contour changes. These structural variations mean the skin and tissue drape unevenly, creating visible shadows.
🔹 Treatment Approach
With dermal fillers placed via cannula, we can soften the transition — filling the dips, smoothing the surface, and balancing light reflection. Think of it as creating a seamless blend between skin and bone so the forehead reflects light evenly, not in patches.
💡 From anatomy to aesthetics, understanding both soft tissue and bony contributions is key to a natural, smooth result.
#dermalfillertraining #aestheticmedicine #harleystreetinstitute #cosmedocs #dermalfiller #hsifellowship #aesthetictraining
online course available for this www.harleystreetinstitute.com
Just watch and learn, most likely you will ever have to do this again, but something similar!
#nosejob #hsifellowprogram







