One of the most common complications that follow the aesthetic procedures performed in the lid area is lower eyelid edema. It can also result following the dermal fillers treatment. Peri-orbital swelling can be caused following the upper face dermal fillers treatment with hyaluronic acid filler. It has been reported to be linked with the various fillers. The swelling in the lower eye-lid can occur due to the migration of the filler from the malar region. Some patients reported the peri-orbital swelling and diplopia following the fillers treatment with hyaluronic acid based dermal fillers. In some others, even a little amount of dermal filler can lead to constant peri-orbital or malar edema which may last longer than effects of the filler, itself.
Note: oedema/swelling arising hours after treatment can be improved with the use of anti-histamines & anti-inflammatories.
That usually occurs when the injector does not have complete and in-depth understanding of the facial anatomy in areas where he is injecting the fillers. It should be injected deeper into the malar area to avoid this complication.
A study was conducted in which diplopia and lower eye-lid swelling was treated with injection of hyaluronidase (source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063423/). It is an enzyme which metabolizes hyaluronic acid. It has been found that the cross linked hyaluronic acids are vulnerable to hydrolysis process caused by injection of hyaluronidase. Most of the hyaluronidase has ovine(Vitrase®, Bausch&Lomb, Rochester) or bovine (e.g. Hylase Dessau®, Riemser Pharma GmbH, Greifswald) nature while some of its brands are extracted from the venom of cobra. So before using, it is better to conduct a skin test for checking any possibility of allergic reactions.
The brand of hyaluronidase that is commonly used in UK is Hyalase (Wockhardt UK Ltd). It is available in 1500 unit ampoule and is a prescription only drug. A study has been conducted on 14 patients to test the efficacy of hyaluronidase in resolving peri-orbital oedema that is associated with the dermal fillers treatment. The results showed that it quickly resolved the swelling of eyelid following single treatment (source: S Hilton, H Schrumpf, BA Buhren, E Bölke, PA Gerber, ‘Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients’.European Journal of Medical Research, (2014) 19(1):30). There were no adverse effects of the treatment and the swelling permanently subsided in the patients who had dermal fillers associated swelling.
How hyaluronidase works?
Hyaluronidase lowers the viscosity of hyaluronan and thereby increasing tissue permeability; it is commonly mixed in tumescent anaesthesia during liposuction. It has also been recommended for treating some adverse reactions to the Hyaluronic acid fillers as its enzymatic activity degrades hyaluronic acid; innate & exogenous. The results of another review study conducted by Berthold Rzany and colleagues, suggested that the treatment with hyaluronidase is safe and effective (source: http://www.laserepilation.ch/files/5113/6386/6556/Hyaluronidase-in-the-correction-of-hyaluronic-acid-based-llers.pdf). By injecting almost 20 units of hyaluronidase peri-orbital swelling or malar edema can be quickly resolved caused as a result of hyaluronic acid filler treatments.
To reconstitute hyalase.
The hyaluronidase is reconstituted with normal saline and is injected slowly right into the center of dermal filler product that is to be removed. It should be reviewed after 24 hours to see the final effects.
There has been considerable evidence and clinical studies which support that the use of hyaluronidase in treating the peri-orbital swelling and malar edema is effective and helps in completely resolving the problem without any further complications.
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3 Comments
I had hyaluronic acid filler inserted into the upper cheek area just under the eyes. Left side was always lumpy and the doctor told me to gently massage and it will eventually smooth out. About a month and a half later I started with severe facial swelling and pain. The doctor placed me on steroids and antibiotics which seemed to help. Once I was off the steroids the symptoms would return only more severe causing headaches and is getting closer to the eyes. More steroids and antibiotics over the course now of 2 months. Two hyaluronidase treatments to help get rid of the filler with no positive results. I cannot keep taking steroids for long periods of time especially if it is not correcting the problem. What are my other treatment options? How do I get rid of this filler?
Hi Joeann,
I am having the exact same issue. How did it turn out for you? Was it ever resolved?
Help. Surgeon injected PLLA (at one point right into my right orbital bone. I am still suffering with chronic pain, swelling – this is over ten years, also in my lower lip. Would an MRI or CT help a qualified surgeon (Opth. reconstruction) fix the inflammation/infected bone? Would it be a different surgeon to go inside the lower lip and “try to get three of the painful clumps out”?
I feel so stupid his believing words…. Is there any help, I get my hopes up, but when a surgeon agrees, quick consults, they might not know what is under the skin…. So much inflammation, somehow he injected into blood vessels under the end and nerves in lower lip. Any suggestions, PLEASE.